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The world's first postpartum depression drug Zulresso is released in the United States and has been approved by the US FDA for $ 7,450

发布日期: 2019年03月22日 Source: Observer NetworkRelease Date: March 22, 2019 Maternity care

In recent years, tragedies caused by postpartum depression often appear in the public eye, but they have not received enough attention. Many mothers who suffer from postpartum depression are often mistaken by their loved ones as "correcting emotions" and have passed the course of the disease by saying "being a mother is just".

Yesterday, the US Food and Drug Administration (FDA) approved the first new drug in history to specifically target postpartum depression. This once again triggered discussions among Chinese mothers on the topic of postpartum depression on domestic social platforms. Some netizens praised it, and the problem of postpartum depression, a global woman, finally began to get attention.

However, although the drug works quickly, netizens say they are "more depressed" when they see the price. Some netizens changed their perspectives: there are family members who are willing to spend huge sums of money for their own diseases. Such mothers rarely have depression. According to the reporter's understanding, some domestic new-born mothers' postpartum depression (or obstacles) may be caused by external factors such as postpartum family conflicts, and not physiological itself.

Fast, but $ 34,000 per course

According to the FDA website, the agency approved Zulresso (also known as brexanolone), an anti-postpartum depression drug developed by SAGE Therapeutics. This medicine will be administered to patients by intravenous injection in a medical institution that has been certified for risk assessment and mitigation strategy (REMS).

The advantage of this medicine is that it has "rapid effect".

A research report released by SAGE pointed out that after taking Zulresso for several days, patients' depression symptoms were greatly improved. The New York Times reports that patients who use the drug for 48 hours will begin to alleviate moderate to severe depression.

Before the advent of this drug, patients with postpartum depression must take other antidepressants, and it takes 2-4 weeks to take effect.

In addition, Zullesso rarely enters breast milk, and patients can resume breastfeeding within days after taking the medication.

But the shortcomings of this drug are also obvious: expensive!

According to the SAGE website, each bottle of Zullesso retails for $ 7,450, and each treatment is equivalent to $ 34,000. This medicine is not yet on the market, and related medical insurance benefits are unknown.

Second, the duration of a course of treatment is 2.5 days, and the patient must be infused continuously for 60 hours. Patients may develop drowsiness and even syncope during the process, and need to be accompanied by medical staff. It should be noted that SAGE emphasizes that patients cannot be alone with their children during the infusion process and need to be accompanied.

The main problem is the unknown duration of the drug.

When SAGE tested the drug between 2016 and 2017, it tracked more than 200 patients who had taken Zullesso for 30 days, and found that 94% of patients did not have recurrent postpartum depression. In response, the company said, "This medicine is effective once within 30 days."

But postpartum depression does not come back.

Sun Jiayi, a national second-level psychological counselor, revealed in an interview with Surging News in January 2017 that "postpartum depression has its time diagnostic criteria-first onset within six months after delivery, and there are many women in the clinic. There are hidden dangers of depression, but postpartum depression worsens because of pregnancy and inability to take medicine. For prenatal patients who have no history of depression and simple postpartum sequelae, we usually give them positive guidance on behavioral cognition, generally in Postpartum depression patients will heal within 3 to 6 months of onset, and a very small number of patients will continue for 1 to 2 years, get pregnant again, and have a recurrence rate of 20% to 30%. "

"A family is willing to pay $ 34,000,

Such people rarely get depressed. "

When this ??百乐宫网上游戏?? came out, it caused a lot of sensation on Weibo. After weighing the pros and cons of Weibo, the author of the Weibo certified fruit shell website @ 游 识 猷 believes that, no matter what, finally started to have a drug specifically for postpartum depression.

Some netizens think about their postnatal life and want to go back and help themselves. "Although it's expensive, I'm relieved that finally there are postpartum antidepressants."

Immediately, some netizens said that the new mother may not have to worry about the child for 2 and a half days, or let the child share the responsibility with his father, and depression will be better.

Others feel that they want to give themselves a shot when they see the effect, but they are more depressed when they see the price. Then there was an opinion that some family members were willing to pay the $ 34,000, and that such people rarely get postpartum depression.

Indeed, postpartum depression is not just a symptom of maternal hormone levels.

Sun Jiayi pointed out that within six months after the birth of a child, it is often a period of high incidence of family conflicts. Disagreements around children ’s eating, drinking, and lazah, and different parenting concepts may trigger family wars. At this time, it is particularly important for the husband and family to understand the care of the mother.

On January 6, 2017, in a community in Xiangtan City, Hunan Province, a 31-year-old mother wrote a testament and took her two-year-old son and a few-month-old daughter to jump from the 13th floor and send He died after treatment. The testament mentioned that after suffering up to 22 hours of childbirth, the first day after the baby was born, her husband without medical knowledge asked her in public whether she had a sexually transmitted disease.

"Postpartum depression is not only a problem for the maternal alone. The husband and family also need to have relevant knowledge to understand how to face it." Sun Jiayi said, "Similarly, for patients with postpartum depression, the husband and family's knowledge reserve and active guidance. is crucial."

"Mother is just" Why?

The concept of postpartum depression has not received enough attention in China.

There is no diagnostic standard for postpartum depression in China. The domestic medical consulting organization "Clove Garden" pointed out in April 2017 that according to the American Psychiatric Association (APA) DSM-5 severe disorder diagnostic criteria, new mothers have frequently or almost every day shown the following 5 in the past two weeks. Or more symptoms can be judged as postpartum depression.

In addition, there are currently no large-scale epidemiological surveys of this type of depression in China. There are only a few small-scale regional surveys, and the data vary widely. Dr. Lilac cited a set of data from the 2014 Expert Consensus on Postpartum Depression Prevention Guidelines at the end of last month:

"The prevalence rate in China is 1.1% -52.1%, with an average of 14.7%, which is basically consistent with the internationally recognized prevalence rate of 10% -15%."

Finally, there are only a few hospitals in Beijing, Shanghai, Shenzhen, and other developed regions in China that are conducting pilot screening and intervention for postpartum depression. "Clove Garden" believes that with the full opening of the "second child policy", the recurrence of postpartum depression may also become severe.

Just one month ago (February 24), a falling incident occurred in a residential building in Anyang Road, Nanning: a pair of mothers and children successively fell from the 31st floor of the community, a 25-year-old mother died on the spot, and a 4-year-old boy Medical rescue died.

Afterwards, a resident revealed via WeChat circle of friends that the young mother had severe postpartum depression. On the day of the incident, the couple had a quarrel for some reason. After the mother threw the child downstairs, she also jumped down.

This incident aroused great concern of the deputies to the NPC and CPPCC during the two sessions.

According to Wenhui News, Ding Xiaobing, a deputy to the National People's Congress and a recipient of the 2016 National May Day Medal, suggested that the content of depression prevention and control should be added to the textbooks of middle schools to promote depression knowledge.

He said: "If the husband knew the dangers of postpartum depression and how to prevent and take care of patients with depression, I think this tragedy can be avoided. I suggest that the content of prevention and treatment of depression be added to the middle school health textbooks. Grab it and spread people's knowledge about depression. "

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Reviews

Le Mom

  • (Visitors) 7 days ago

Reply to the topic: “Central suspension without school suspension” was deflected and attracted the public. The Ministry of Education answered questions about the “School suspension without school suspension” related to the postponement of primary and secondary schools.

While asking our parents to return to work, it is homework for various groups in the school. It is a sophomore, Chinese, mathematics, English, music, sports, art, and so many groups. Parents must accompany their children to read and complete the tasks. Then take pictures, videos! Then, parents are back to work. How can these homework be completed? Is it time to return from work? It's really unreasonable. Parents are tired.

Luo Jiahui

  • (Visitors) 7 days ago

Reply to the topic: “Central suspension without school suspension” was deflected and attracted the public. The Ministry of Education answered questions about the “School suspension without school suspension” related to the postponement of primary and secondary schools.

I think the health of students is very important now, especially under the background of this student, there are already a large number of students with myopia. Why does the school education even force students to watch it so that glasses ca n’t work in a day, I I am a senior in high school. I have to stare at the screen for at least four hours a day. The glasses are really tired, and it takes about seven or eight hours a day to do questions on the screen. The glasses are really too high.

Oops

  • (Visitors) 7 days ago

Reply to the topic: “Central suspension without school suspension” was deflected and attracted the public. The Ministry of Education answered questions about the “School suspension without school suspension” related to the postponement of primary and secondary schools.

Teachers, parents, and children all torture each other. Actually, the kindergarten also recorded online lessons. I did n’t think it was necessary for my second grade. The teacher could arrange special homework, copy papers, diary and manual. The damage to the eyes is great, and the loss is worth it.

Yunpiao

  • (Visitors) 7 days ago

Reply to the topic: “Central suspension without school suspension” was deflected and attracted the public. The Ministry of Education answered questions about the “School suspension without school suspension” related to the postponement of primary and secondary schools.

I'm curious. Except for the supplementary classes for the junior high school and high school winter vacation, aren't all the elementary and middle schools yet to start? Generally, it is around February 25 every year. Why are there live lectures everywhere? How are the students' schedules arranged? Looking at parents' phones all day long?

The commoner is far away

  • (Visitors) 7 days ago

Reply to the topic: “Central suspension without school suspension” was deflected and attracted the public. The Ministry of Education answered questions about the “School suspension without school suspension” related to the postponement of primary and secondary schools.

Suspension and non-stop online teaching is to make head decisions, without considering the actual situation of each teacher or student, can it be equipped? Non-graduate classes may be delayed for the summer vacation and shortened.

Live the Royal Sister Rice

  • (Visitors) 8 days ago

Reply to the subject: Wuhan million elementary and middle school students start online classes, unified lessons in the morning, personalized coaching in the afternoon, missed live broadcast can watch video playback

I think this form is very good. In the fifth grade, a class is only about 15 minutes. It is very efficient. Think about how much time you usually waste at school. After listening, the child can rest and do his own work. He finishes his homework at six o'clock, and the evening time is all his own.

Zheng Yu brother

  • (Visitors) 8 days ago

Reply to the topic: Wuhan million elementary and middle school students start online classes, unified lessons in the morning, personalized coaching in the afternoon, missed live lessons, see video playback

It looks like a good thing, but it's impractical to think about it a little more, one without teaching materials, two without teaching participants, three without multimedia courseware, and four without classroom feedback and interaction. How to keep the network unblocked? How to ensure everyone's participation? Does the leader feel that the teacher can talk like a speaker for three hours without stopping? Usually carrying the new curriculum standard with students as the main body of the classroom, at this moment, the teacher sang a monologue.

Worchen

  • (Visitors) 8 days ago

Reply to the topic: Wuhan million elementary and middle school students start online classes, unified lessons in the morning, personalized coaching in the afternoon, missed live lessons, see video playback

This is indeed a new transformation. The teacher did not expect that one day it would become a webcast anchor. Maybe one day, the teaching methods changed due to the virus epidemic in the new hall increased the popularity of online education. In fact, from one aspect, this is also necessary for the progress of the times. School education can also be diversified and adapted to different courses on different platforms.

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